Medications for Hemophagocytic Lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH)  is really a lifethreatening illness due to overactive cells of the immune system inducing excessive inflammation, which results in harm to tissue and organs especially the liver, brain, skin and bone marrow.

There are two sorts of HLH HLH and secondary HLH.   Primary HLH is a hereditary illness that`s also called  familial hemophagocytic lymphohistiocytosis (FHL).   Secondary HLH or lymphohistiocytosis that is acquired occurs after having a immune reaction as an example a systemic infection, malignancy or immunodeficiency.

From the immune system once the T cells and NK cells do the job their occupation is really to destroy damaged or infected cells within the body.  But in HLH there is an increase in T cells and a decline in NK cell activity, with a resulting increase in cytokines.  This induces inflammatory reactions that leads in the broad tissue and organ damage and disorders and a protracted macrophage activation.

Indicators of HLH usually are rash, and fever, enlarged lymph nodes, enlarged liver and spleen, swollen gums and gastrointestinal problems. In case HLH is, it can progress to collapse.  Therapy for HLH is directed toward reducing the life-threatening inflammation.